Interphase cytogenetics for studying solid tumors
نویسندگان
چکیده
منابع مشابه
What should oncologists know about cytogenetics in solid tumors?
Despite the fact that gross chromosome changes in malignant tumors were first described in human solid tumors more than 100 years ago by Arnold [1], cytogenetic analysis of solid tumors is still in its infancy compared to studies of leukemic cells [for review see 2, 3]. Advances in solid tumor cytogenetics have been and still are at the mercy of methodology, with the most limiting factors being...
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Although presently known as an environmentally-related disease and appears mostly sporadic, cancer is regarded as a genetic disease based on the presence of gene mutation as a consistent factor. The "Philadelphia Chromosome" found consistently among chronic myeloid leukemia (CML) patients was the first significant finding of a chromosomal abnormality specifically related to a particular disease...
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Although presently known as an environmentally-related disease and appears mostly sporadic, cancer is regarded as a genetic disease based on the presence of genetic mutation as a consistent factor. The “Philadelphia Chromosome” found consistently among chronic myeloid leukemia (CML) patients was the first significant finding of a chromosomal abnormality specifically related to a particular dise...
متن کاملInterphase cytogenetics of workers exposed to benzene.
Fluorescence in situ hybridization (FISH) is a powerful new technique that allows numerical chromosome aberrations (aneuploidy) to be detected in interphase cells. In previous studies, FISH has been used to demonstrate that the benzene metabolites hydroquinone and 1,2,4-benzenetriol induce aneuploidy of chromosomes 7 and 9 in cultures of human cells. In the present study, we used an interphase ...
متن کاملInterphase Cytogenetics of Lung Tumors Using In Situ Hybridization: Numerical Aberrations
OBJECTIVES Since conventional cytogenetic analysis for bronchogenic carcinogenesis is limited by the difficulty to get enough number of high quality metaphase spreads, the development of new method to overcome above problems is strongly needed. Therefore, the introduction of non-radioactive in situ hybridization (ISH) with pericentromeric chromosome probes gave us the way to investigate the gen...
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ژورنال
عنوان ژورنال: Cancer
سال: 1998
ISSN: 0008-543X,1097-0142
DOI: 10.1002/(sici)1097-0142(19980901)83:5<839::aid-cncr5>3.0.co;2-d